Thousands flocked to Tahrir Square Friday to demand President Mohamed Morsy's stand down and hold early presidential elections.
Protesters chanted against Morsy and the Brotherhood.
"Down with the rule of the supreme guide," demonstrators chanted, echoing calls heard across Egypt on Friday against Muslim Brotherhood Supreme Guide Mohamed Badie. "Leave!" others could be heard chanting.
"The people want to bring down the regime," the crowds said.
Entrances to Tahrir Square, except the road from Simon Bolivar Square, have been closed since Friday morning with metal barriers.
Traffic has been prevented from entering the square as more marchers join the protests.
Popular committees were stationed at entrances to inspect IDs, in attempts to prevent criminals infiltrating the expressly peaceful protest.
